Unlocking Nature’s Potential for Breakthrough Therapies with DTIGN

Nanyang Biologics' AI-driven DTIGN platform revolutionizes natural compound drug discovery with great accuracy, efficiency, and speed, unlocking nature's vast therapeutic potential for breakthrough treatments.

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Nature has always been our greatest healer – over 50% of FDA-approved drugs originate from natural compounds. Yet, we have only explored a fraction of Earth's biodiversity for therapeutic potential. What if we could harness AI to unlock these hidden treatments faster than ever before?

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The Challenge of Natural Compounds in Drug Discovery

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The traditional process of identifying and refining natural compounds into viable therapies involves several critical hurdles:

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1) Extensive screening: Only a fraction of Earth’s biodiversity has been explored, and even fewer compounds have been tested for therapeutic applications. A study by Veeresham estimates that out of approximately 391,000 known plant species, only 35,000 - 70,000 have been investigated for their potential medicinal use, leaving a vast untapped reservoir of biodiversity.

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2) Complex molecular structures: Natural compounds are chemically complex, often comprising thousands of unique molecules, making them difficult to isolate, analyze, and optimize for drug development. According to Paul et al., just one out of every 10,000 screened compounds typically advances to clinical trials, highlighting the complexity of this process.

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3) High costs & long timelines: Discovering new natural compounds, identifying the right molecules, and refining them into viable treatments remains a labor-intensive and costly process. On average, Deloitte estimates that it takes over 12 years and $2 billion to bring a new treatment or therapy to market.

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DTIGN: Harnessing Natural Compounds with Cutting-Edge Technologies

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At Nanyang Biologics, we are shaping a future where healthcare treatments are accessible, effective, and elevate the quality of life for all. Central to this vision is our groundbreaking AI-driven DTIGN platform, which is revolutionizing the field of natural compound drug discovery. By addressing long-standing challenges in the industry, DTIGN is unlocking the vast therapeutic potential of nature, paving the way for innovative treatments that were once thought impossible.

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DTIGN’s true edge lies in its exceptional precision compared to traditional methods:

• 27.03% improvement in bioactivity prediction accuracy
• 64-fold increase in hit rate efficiency
• 68.2% reduction in drug discovery timelines

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DTIGN’s superior accuracy empowers us to confidently screen our vast library of bioactive compounds from nature, unlocking new opportunities for breakthrough treatments. This capability is essential because it allows us to unlock the full potential of natural drug discovery.

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The potential of natural compounds in drug discovery is further underscored by recent research. A study conducted by Domingo-Fernández et al. showed that drugs derived from or inspired by nature are more likely to survive clinical trials. Specifically, the proportion of studied natural product-based compounds from clinical trials increased from 20% in Phase I to 26% in Phase III, in contrast to synthetic compounds, which showed a declining trend throughout the phases. Natural compounds and their derivatives were also shown to be less toxic alternatives to their synthetic counterparts. These discoveries offered valuable insights for natural compound-based drug discovery, highlighting the potential benefits of prioritizing them as starting points.

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Additionally, natural compounds are often highly complex, with intricate molecular architectures that are difficult to replicate synthetically. In many cases, these structures cannot be fully synthesized, or they are too difficult and expensive to produce on an industrial scale, making extraction from natural sources the most viable and practical option. This complexity is precisely what gives natural compounds their unique therapeutic potential, as their intricate designs often enable them to interact with biological systems in ways that synthetic molecules cannot. By systematically screening and analyzing these natural compounds, we are not only accelerating the pace of discovery but also ensuring that the treatments we develop are rooted in the proven efficacy and safety of natural compounds.

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We believe that the future of medicine lies in the synergy of nature and technology. By pioneering innovative solutions like DTIGN, we are committed to accelerating drug discovery and unlocking meaningful health and wellness solutions. As we continue our journey, we remain dedicated to transforming natural insights into impactful healthcare advancements, shaping a healthier, more accessible future for all.

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Join us in revolutionizing drug discovery. Explore more about DTIGN and our mission at Nanyang Biologics!